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Clinical Implications of Basic Research
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Volume 353:2712-2713 December 22, 2005 Number 25
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Immunosuppression, Skin Cancer, and Ultraviolet A Radiation
John A. Parrish, M.D.

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Skin cancer is a serious problem in immunosuppressed patients. In these patients, cutaneous cancers are common in areas of the skin that are exposed to the sun, are more aggressive than in patients who are not immunosuppressed, are sometimes fatal, and often require multiple surgical procedures.1 Although the absolute risk of squamous-cell carcinoma after renal transplantation is highest in sunny climates, the risk of these tumors is also greatly elevated in less sunny areas. For example, a study of more than 700 renal-transplant recipients in the Netherlands disclosed that the overall incidence of squamous-cell carcinoma was 250 times that in . . . [Full Text of this Article]


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From the Department of Dermatology, Massachusetts General Hospital, Boston.



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