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Volume 353:2718 December 22, 2005 Number 25
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Protective Conditioning for Acute Graft-versus-Host Disease

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 by Lowsky, R.
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To the Editor: Lowsky et al. (Sept. 29 issue)1 report a conditioning regimen associated with an impressively low incidence of graft-versus-host disease (GVHD). However, the dynamics of engraftment are unclear. The authors mention that "donor T cells subsequently declined in number and were markedly reduced or undetectable within 75 to 200 days after transplantation in 6 of the 37 patients." This finding suggests that late graft failure occurred in a substantial proportion of patients and consequently could in part explain the low incidence of GVHD.

In addition, in the setting of nonmyeloablative transplantation, the time to the onset of acute . . . [Full Text of this Article]




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