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Correspondence
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Volume 353:2818-2820 December 29, 2005 Number 26
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Passive Immunization against Cytomegalovirus during Pregnancy

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 by Nigro, G.
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To the Editor: Nigro et al. (Sept. 29 issue)1 report on the administration of cytomegalovirus (CMV) hyperimmune globulin to 68 pregnant women with primary CMV infection and conclude that this treatment "may be effective in the treatment and prevention of congenital CMV infection." However, 39 of 45 newborns with amniocentesis-proven congenital infection still shed virus at birth, and in utero infection was never documented in the remaining 84 newborns in the "prevention" group (in which women who had a recent primary infection before 21 weeks' gestation or who declined amniocentesiswere offered monthly hyperimmune globulin), only 37 of whose mothers received . . . [Full Text of this Article]




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