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Volume 353:2821-2822 December 29, 2005 Number 26
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Chaperones and Disease

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by Macario, A. J.L.
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To the Editor: In Table 3 of their excellent review, Macario and Conway de Macario (Oct. 6 issue)1 state that an elevated level of circulating heat-shock protein (HSP) 70 has not been associated with any disease. However, we recently described elevated levels of circulating HSP70 in sickle cell disease.2 The increase in the level of HSP70 probably contributes to cytokine activation, since the protein may be released as a consequence of cell damage resulting from repeated episodes of ischemia–reperfusion injury.3,4


Adeboye H. Adewoye, M.D.
Boston Medical Center
Boston, MA 02118
hadewoye@bu.edu


Lillian McMahon, M.D.
Center of Excellence in Sickle Cell . . . [Full Text of this Article]



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