Pregnancy after Transplantation of Cryopreserved Ovarian Tissue in a Patient with Ovarian Failure after Chemotherapy

doi:10.1056/NEJMc055237

Volume 353:318-321		July 21, 2005		Number 3

Pregnancy after Transplantation of Cryopreserved Ovarian Tissue in a Patient with Ovarian Failure after Chemotherapy

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To the Editor: Premenopausal women who undergo high-dose chemotherapyhave a very high risk of ovarian failure.¹ Cryopreservationof ovarian tissue with subsequent autotransplantation has effectivelypreserved fertility in an animal model,² but its efficacy inhumans has been uncertain. Eggs that were aspirated from cryopreservedovarian tissue transplanted in heterotopic sites did not resultin a pregnancy.³ A live birth was reported after transplantationof cryopreserved ovarian tissue in a woman who had undergonetreatment for Hodgkin's disease; however, since the woman hadovulated before transplantation, it is uncertain whether theegg came from the native ovary or the . . . [Full Text of this Article]

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