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Volume 353:429-430 July 28, 2005 Number 4
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Inflammation, Atherosclerosis, and Coronary Artery Disease

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by Hansson, G. K.
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To the Editor: In his review of inflammation, atherosclerosis, and coronary artery disease, Hansson (April 21 issue)1 focuses on T cells, macrophages, and mast cells as the cellular components of the immune system that play a key role in ischemic heart disease. However, he omits a possible role for neutrophils.

Several lines of evidence support the possibility that these cells are involved in this condition. Early studies showed a strong positive correlation between peripheral-blood neutrophil counts and the risk of acute myocardial infarction2 and documented the presence of activated circulating neutrophils in acute coronary syndromes.3 Furthermore, infiltration by neutrophils of . . . [Full Text of this Article]



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