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Previous Volume 353:525-528 August 4, 2005 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Long-term antichlamydial antibiotic therapy did not alter the risk of cardiac events among patients with stable coronary disease, as reported by Grayston et al.,¹ or after an acute coronary syndrome, as reported by Cannon et al.² (April 21 issue). Unfortunately, neither of these studies used baseline serologic tests during patient selection. Consequently, only one third of patients had IgA antibody,¹ and only 3.5 percent had chlamydial DNA in peripheral mononuclear blood cells.² In the absence of persistent chlamydial infection among the majority of treated patients, there is little reason to expect a clinical benefit with antichlamydial treatment.

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