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Previous Volume 353:604-615 August 11, 2005 Number 6 Next

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The metabolic syndrome, also known as syndrome X, is characterized by abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance, inflammation, and prothrombotic states.¹ Diagnostic of the metabolic syndrome are abnormalities in three or more of the clinical criteria of the Adult Treatment Panel III of the National Cholesterol Education Program, which include the following: a waist circumference of more than 102 cm in men and more than 88 cm in women; a triglyceride level of 150 mg per deciliter or more; a level of high-density lipoprotein (HDL) cholesterol of less than 40 mg per deciliter in men and less than 50 . . . [Full Text of this Article]

Reverse Endocrinology of RXR Heterodimers

RXRs: Partners in Signaling

PPARs: Fatty-Acid Sensors

PPAR

PPAR

PPAR

LXRs: Sterol Sensors

FXR: Bile Acid Sensor

Thyroid Hormone Receptors

Perspectives

Source Information

From the Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas.

Address reprint requests to Dr. Mangelsdorf at the University of Texas Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390, or at davo.mango@utsouthwestern.edu.

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Retinoid X Receptor Heterodimers in the Metabolic Syndrome
Hegele R. A.
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N Engl J Med 2005; 353:2088, Nov 10, 2005. Correspondence

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