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Previous Volume 354:54-66 January 5, 2006 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Autoimmune hepatitis is a generally progressive, chronic hepatitis of unknown cause that occurs in children and adults of all ages. Occasionally, it has a fluctuating course, with periods of increased or decreased activity. The diagnosis is based on histologic abnormalities, characteristic clinical and biochemical findings, and abnormal levels of serum globulins, including autoantibodies. Since the first descriptions of this disorder more than 50 years ago,¹ many labels have been applied, but "autoimmune hepatitis" has been accepted as the most appropriate and least redundant term.^2,3 Variant, overlapping, or mixed forms of autoimmune hepatitis that share features with other putative autoimmune liver . . . [Full Text of this Article]

Pathogenesis

Potential Triggers

Genetic Susceptibility

Mechanisms of Aberrant Autoreactivity

Clinical Characteristics

Presentation

Laboratory Abnormalities

Classification and Autoantibodies

Complications

Histologic Appearance

Diagnosis

Variant Syndromes

Treatment

Standard Treatment

Other Therapy

Treatment of Variant Syndromes

Liver Transplantation

Summary

Source Information

From the Department of Medicine, University of Vermont, Burlington; and the Department of Medicine, Dartmouth College, Hanover, N.H.

Address reprint requests to Dr. Krawitt at the University of Vermont, Given C-246, Burlington, VT 05405-0068, or at edward.krawitt@uvm.edu.

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