Chronic infection with hepatitis B virus (HBV) accounts foran enormous burden of disease worldwide, including up to halfof all cases of cirrhosis, end-stage liver disease, and hepatocellularcarcinoma.1 With the development of a safe and effective vaccinein the early 1980s, hepatitis B became a preventable disease.Routine HBV vaccination of newborns in Taiwan and China, areasof the world with high rates of hepatitis B, was followed bysignificant declines in rates of chronic hepatitis B and hepatocellularcarcinoma.2 In the United States, where the disease is uncommon,the incidence of new cases is currently 75 percent . . . [Full Text of this Article]
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From the Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md.
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