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Previous Volume 354:1091-1093 March 9, 2006 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The Sildenafil Use in Pulmonary Hypertension (SUPER) trial (Nov. 17 issue)¹ has led to the approval of sildenafil for the treatment of pulmonary arterial hypertension by the Food and Drug Administration and its European counterpart, the European Medicines Agency. Although the availability of a new treatment is embraced, the agencies have created a major problem by restricting the sildenafil dose to 20 mg three times a day. The SUPER trial involved three doses — 20 mg, 40 mg, and 80 mg three times a day. Although all doses had similar effects with regard to the distance walked . . . [Full Text of this Article]

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