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Previous Volume 354:1093-1094 March 9, 2006 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Häberle et al. (Nov. 3 issue)¹ state that "the concentration of glutamate . . . was not elevated in either of the two patients, but this lack of elevation might be due to the various other pathways of glutamate catabolism." We suggest that low-to-deficient glutamate concentrations in cerebrospinal fluid indicate a chronic depletion of neuronal glutamate stores, since astrocytic glutamine synthase is crucial for their replenishment. After the bioenergetic coupling of and metabolite trafficking between astrocytes and neurons occur,² a complete deficiency of this enzyme should result in a severe depletion of neuronal glutamate stores in the long run . . . [Full Text of this Article]

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