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Editorial
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Volume 354:1189-1190 March 16, 2006 Number 11
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Play It Again, Sam — Depression Is Recurring
Burton V. Reifler, M.D., M.P.H.

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-Related Article
 by Reynolds, C. F.
-PubMed Citation
Many years ago I read an editorial, author and journal now forgotten, that included in its title the phrase, "Play it again, Sam" — words attributed to, but never actually spoken by, the character played by Humphrey Bogart in the film Casablanca. I can think of no better phrase by which to emphasize the point of this editorial: again and again, research has shown that depression is an illness with a high degree of recurrence.

It is difficult to overstate the effect depression has on health. The World Health Organization lists depression as the leading cause worldwide of years . . . [Full Text of this Article]


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From the Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, N.C.


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