FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 354:1204-1205 March 16, 2006 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Calin, G. A. PubMed Citation

To the Editor: Calin et al. (April 21, 2005, issue)¹ proposed that the truncating sequence change in ARLTS1, G446A (Trp149Stop), predisposes persons to a wide range of malignant conditions including chronic lymphocytic leukemia (CLL). The assertion that this variant predisposes persons to CLL was, however, based on observations from only 17 familial patients of mixed ethnic background.

We conducted an association study to determine if this variant or five other coding single-nucleotide polymorphisms (cSNPs) in ARLTS1 predispose to CLL. We analyzed germ-line DNA from 413 patients with CLL (259 men and 154 women; mean age, 58 years; range, 33 to . . . [Full Text of this Article]

This article has been cited by other articles:

• Castellvi-Bel, S., Castells, A., de Cid, R., Munoz, J., Balaguer, F., Gonzalo, V., Ruiz-Ponte, C., Andreu, M., Llor, X., Jover, R., Bessa, X., Xicola, R. M., Pons, E., Alenda, C., Paya, A., Carracedo, A., Pique, J. M., for the Gastrointestinal Oncology Group of the Spa, (2007). Association of the ARLTS1 Cys148Arg variant with sporadic and familial colorectal cancer. Carcinogenesis 28: 1687-1691 [Abstract] [Full Text]  
• Petrocca, F., Iliopoulos, D., Qin, H. R., Nicoloso, M. S., Yendamuri, S., Wojcik, S. E., Shimizu, M., Di Leva, G., Vecchione, A., Trapasso, F., Godwin, A. K., Negrini, M., Calin, G. A., Croce, C. M. (2006). Alterations of the Tumor Suppressor Gene ARLTS1 in Ovarian Cancer. Cancer Res. 66: 10287-10291 [Abstract] [Full Text]