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Previous Volume 354:1273-1280 March 23, 2006 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 25-year-old woman presents with a one-week history of blurred vision in the left eye. One day before the onset of visual loss, she noted a dull ache in the left periorbital region accompanied by pain on eye movement. Her symptoms progressed for three days but have not worsened since. The patient has no history of other visual or neurologic symptoms. Examination . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Diagnosis

            History and Physical Examination

            MRI

            Other Methods of Diagnosis

Short-Term Treatment

Long-Term Therapy

Areas of Uncertainty

High-Dose Oral Corticosteroids

Interferon Therapy

Intravenous Immunoglobulin

Pediatric Optic Neuritis

Guidelines

Summary and Recommendations

Source Information

From the Division of Neuro-ophthalmology, Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia.

Address reprint requests to Dr. Balcer at the Department of Neurology, 3 East Gates, 3400 Spruce St., Philadelphia, PA 19104, or at lbalcer@mail.med.upenn.edu.

Related Letters:

Optic Neuritis
Dorfman L., Balcer L. J.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:212, Jul 13, 2006. Correspondence

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• Balcer, L. J., Galetta, S. L., Calabresi, P. A., Confavreux, C., Giovannoni, G., Havrdova, E., Hutchinson, M., Kappos, L., Lublin, F. D., Miller, D. H., O'Connor, P. W., Phillips, J. T., Polman, C. H., Radue, E. -W., Rudick, R. A., Stuart, W. H., Wajgt, A., Weinstock-Guttman, B., Wynn, D. R., Lynn, F., Panzara, M. A., for the AFFIRM and SENTINEL Investigators, (2007). Natalizumab reduces visual loss in patients with relapsing multiple sclerosis. Neurology 68: 1299-1304 [Abstract] [Full Text]  
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