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Previous Volume 354:1281-1293 March 23, 2006 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The first child born to a transplant recipient turned 48 years old on March 10, 2006.¹ When the field of transplantation was first developing, physicians worried about the teratogenicity of immunosuppressive medications² and considered pregnancy ill-advised.^3,4 Despite early concerns, approximately 14,000 births among women with transplanted organs have been reported worldwide,⁵ and many more have assuredly occurred. Pregnancy is now an expected part of the benefits afforded to women by organ transplantation.

However, substantial gaps remain in our knowledge about pregnancy in the transplant recipient and its effects on the child. As discussed in an article by Ross that appears . . . [Full Text of this Article]

Sources of Information about Pregnancy in Transplant Recipients

Fertility, End-Stage Disease, and Transplantation

Optimal Timing of Pregnancy after Transplantation

Risk of Pregnancy Complications in the Transplant Recipient

            Hypertension and Preeclampsia in Pregnant Kidney-Transplant Recipients

            Hypertension and Preeclampsia in Pregnant Recipients of Other Solid-Organ Transplants

            Risk of Allograft Loss

            Pregnancy and the Risk of Rejection

Immunosuppressive Medications and the Maternal–Fetal Circulation

Immunosuppressive Medications and the Fetus

Toxic Effects of Immunosuppressive Agents in Pregnancy

Structural Malformations in Animal Models

Structural Malformations in Children of Transplant Recipients

            Drug-Induced Immunologic Abnormalities in the Fetus and Newborn

Long-Term Consequences of in Utero Exposure to Immunosuppressive Medications

Breast-Feeding by Mothers Receiving Immunosuppressive Medication

Conclusions

Source Information

From the Department of Immunology, Scripps Research Institute, La Jolla, Calif. (D.B.M.); and the Department of Medicine, Section of Nephrology, University of Chicago, Chicago (M.A.J.).

Address reprint requests to Dr. McKay at the Department of Immunology, Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, or at dmckay@scripps.edu.

Related Letters:

Pregnancy in Recipients of Solid-Organ Transplants
Padhan P., McKay D. B., Josephson M. A.
Extract | Full Text | PDF  
N Engl J Med 2006; 354:2726-2727, Jun 22, 2006. Correspondence

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• NAIR, A., STEGA, J., SMITH, J. R., DEL PRIORE, G. (2008). Uterus Transplant: Evidence and Ethics. Ann. N. Y. Acad. Sci. 1127: 83-91 [Abstract] [Full Text]  
• McKay, D. B., Josephson, M. A. (2008). Pregnancy after Kidney Transplantation. CJASN 3: S117-S125 [Abstract] [Full Text]  
• McGrory, C. H., Ondeck-Williams, M., Hilburt, N., Constantinescu, S., Silva, P., Daller, J. A., Coscia, L. A., Armenti, V. T. (2007). Nutrition, Pregnancy, and Transplantation. Nutr Clin Pract 22: 512-516 [Abstract] [Full Text]  
• Stega, J., Smith, J. R., Sieunarine, K., Ungar, L., Del Priore, G. (2007). Human Uterus Retrieval From a Multiorgan Donor. Obstet Gynecol 109: 1459-1459 [Full Text]  
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