The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Case Records of the Massachusetts General Hospital
Editor's Names
PreviousPrevious
Volume 354:1403-1409 March 30, 2006 Number 13
NextNext

Case 10-2006 — A 66-Year-Old Woman with Barrett's Esophagus with High-Grade Dysplasia
Norman S. Nishioka, M.D., and Gregory Y. Lauwers, M.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-PubMed Citation
Presentation of Case

A 66-year-old woman was referred to the gastroenterology clinic for evaluation and management of Barrett's esophagus with high-grade dysplasia.

Seven months earlier, she had been seen at another hospital because of rectal bleeding. She had occasional heartburn but no dysphagia, anorexia, abdominal pain, or weight loss. Colonoscopy revealed a cecal polyp, which was resected. A histopathological examination revealed a tubulovillous adenoma. Esophagogastroduodenoscopy with biopsy of the distal esophagus showed metaplastic glandular mucosa with goblet cells consistent with a diagnosis of Barrett's esophagus, with high-grade dysplasia. Treatment with lansoprazole (60 mg daily) was started.

A follow-up endoscopic examination and esophageal biopsy . . . [Full Text of this Article]

Pathological Discussion

Dysplasia in Barrett's Esophagus

Discussion of Management

Prophylactic Esophagectomy

Observation

Mucosal Ablation

            Photodynamic Therapy

            Endoscopic Submucosal Resection

Anatomical Diagnosis


Source Information

From the Gastrointestinal Unit (N.S.N.) and the Department of Pathology (G.Y.L.), Massachusetts General Hospital; and the Departments of Medicine (N.S.N.) and Pathology (G.Y.L.), Harvard Medical School.



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.