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Previous Volume 354:1507-1514 April 6, 2006 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Everyone in medicine and related fields understands that there are marked sex-based differences in the epidemiology, clinical manifestations, course, and therapy of disease.¹ Although very few of these differences are understood in molecular or cellular terms, the explanations must derive from the fundamental biologic differences between the sexes. This article reviews the current understanding of hormonal and genetic differences between the sexes.

Fertility in Men and Women

Fertility differs considerably between men and women (Table 1). Men are fertile from puberty through at least the 9th decade of life, and some men are fertile into the 10th decade. Although there is some decrease . . . [Full Text of this Article]

Hormonal Differences between the Sexes

Transport of Sex Hormones

Peripheral Events

Sex Hormones as Somatic Hormones

Genetic Differences between the Sexes

Imprinting

Socioeconomic Factors

Conclusions

Source Information

From Harvard Medical School, Boston.

Address reprint requests to Dr. Federman at Harvard Medical School, 25 Shattuck St., Boston, MA 02115, or at daniel_federman@hms.harvard.edu.

Related Letters:

The Biology of Human Sex Differences
Stanford J. B., Federman D. D.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:98, Jul 6, 2006. Correspondence

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