A nationwide vaccination program may have direct or indirecthealth effects that may be anticipated or unanticipated; althoughthese effects are, of course, intended to be beneficial, somepotentially adverse ones may occur. The full range of such effectsare well illustrated in the important study of the impact ofwidespread administration of the protein-conjugate pneumococcalvaccine PCV-7 (Prevnar, Wyeth) from the Active Bacterial CoreSurveillance of the Centers for Disease Control and Prevention,reported by Kyaw et al. in this issue of the Journal.1
The most obvious direct effect of widespread vaccination ofinfants with protein-conjugated capsular polysaccharides . . . [Full Text of this Article]
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From the Medical Care Line (Infectious Disease Section), Michael E. DeBakey Veterans Affairs Medical Center, and the Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine both in Houston.
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