Although the root cause of asthma is not known, treatments havebeen developed that target facets of the underlying pathologicabnormalities of asthma: airway inflammation, hypersecretionof mucus, and airway hyperresponsiveness. These treatments notonly have improved the site of drug delivery (e.g., inhaledcorticosteroids) but have directly targeted the relevant pathwaysthat contribute to symptoms (e.g., leukotriene modifiers andanti-IgE). Although these treatments have proved to be effective,practitioners are often humbled as the condition progressesdespite their best efforts to control it; therapeutic strategiesthat target unexplored disease associations are needed.
From the Pulmonary Center, Boston University School of Medicine, and the Section of Pulmonary, Allergy, and Critical Care Medicine, Boston Medical Center — both in Boston.
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Caramori G., Papi A., Mutgi A., Hammersley J., Kuramochi Y., Morita T., Osawa R., Andraws R., Johnston S. L., Nieman R. B., the Telithromycin, Chlamydophila, and Asthma Trial Investigators
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N Engl J Med 2006;
355:96-98, Jul 6, 2006.
Correspondence
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