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Previous Volume 354:1636-1638 April 13, 2006 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Type 2 diabetes mellitus is characterized by a relative deficit in insulin secretion, caused by a decrease in the glucose sensitivity of the pancreatic beta cells, by a reduction in their total number, or a combination of both. Not surprisingly, a great deal of effort is expended in understanding the processes that underlie these events and how they go awry in type 2 diabetes. One line of investigation involves dissection of the mechanisms by which glucose triggers insulin secretion; a recent article by Ohtsubo and colleagues¹ underscores an interesting process.

Glucose-stimulated insulin secretion requires the metabolism of glucose, and consequent . . . [Full Text of this Article]

Source Information

From the Department of Physiology and the Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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