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Previous Volume 354:1643-1645 April 13, 2006 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Shankaran et al. (Oct. 13 issue)¹ report improved neurologic outcomes and reduced mortality in newborns with perinatal asphyxia treated with mild hypothermia. This confirms previous observations from one randomized trial and eight nonrandomized studies.^2,3

The accompanying editorial by Papile⁴ concludes that brain cooling for neonates with hypoxic–ischemic encephalopathy should be considered an experimental technique and that widespread application would be premature. Papile suggests that longer-term follow-up will be needed to confirm the benefits in terms of neurologic performance. We feel strongly that this conservatism is misplaced. No other effective treatments for encephalopathy after hypoxia are available; with . . . [Full Text of this Article]

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• Rademaker, C. M.A., de Vries, L. S. (2008). Pharmacology Review: Lidocaine for Neonatal Seizure Management. NeoReviews 9: e585-e589 [Full Text]  
• Statler, K. D. (2008). Hypothermia to Treat Neonatal Hypoxic Ischemic Encephalopathy. AAP Grand Rounds 19: 3-4 [Full Text]  
• Shah, P. S., Ohlsson, A., Perlman, M. (2007). Hypothermia to Treat Neonatal Hypoxic Ischemic Encephalopathy: Systematic Review. Arch Pediatr Adolesc Med 161: 951-958 [Abstract] [Full Text]