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Previous Volume 354:1744-1746 April 20, 2006 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Antiplatelet therapy with aspirin, an irreversible inhibitor of platelet cyclooxygenase, has earned its rightful place as a cornerstone of treatment for reducing cardiovascular events in patients with established vascular disease.^1,2 This statement is based on consistent results favoring aspirin in a large number of randomized, controlled trials in populations with either acute or long-term disease. Clopidogrel, by inhibiting the adenosine diphosphate P2Y₁₂ receptor, offers a distinctly different mechanism to reduce platelet activation and aggregation. As monotherapy, clopidogrel has been shown to be effective in reducing the risk of vascular events in patients with established vascular disease.³

Even more important, when . . . [Full Text of this Article]

Source Information

From Brigham and Women's Hospital and Harvard Medical School (M.A.P.) and the Journal (J.A.J.) — all in Boston.

This article was published at www.nejm.org on March 12, 2006.

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