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Correspondence
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Volume 354:1751-1752 April 20, 2006 Number 16
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Intensive Diabetes Treatment and Cardiovascular Disease

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by Cefalu, W. T.
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by The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group
-PubMed Citation
To the Editor: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study research group (Dec. 22 issue)1 reports that intensive therapy for diabetes reduced the risk of cardiovascular events by 42 percent without any mention of the adverse events associated with such therapy. The article from the DCCT research group2 published in the Journal in 1993 reported the incidence of severe hypoglycemia to be 62 episodes per 100 patient-years in the intensive-therapy group, as compared with 19 such episodes per 100 patient-years in the conventional-therapy group. The cardiovascular-event rates were 0.80 per 100 patient-years and 0.38 . . . [Full Text of this Article]



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