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Volume 354:1752-1753 April 20, 2006 Number 16
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Inhaled Cyclosporine in Lung Transplantation

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 by Iacono, A. T.
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To the Editor: The report by Iacono and colleagues (Jan. 12 issue)1 on the effect of inhaled cyclosporine in lung-transplant recipients raises important questions that need further clarification. Although the authors found that inhaled cyclosporine reduced the two- and three-year prevalence of the bronchiolitis obliterans syndrome, as compared with placebo, it is very surprising in the modern era of lung transplantation to find such a high prevalence of this syndrome: about 70 and 65 percent after two and three years, respectively, in the treated group, on the basis of spirometry, as compared with 50 and 30 percent, respectively, in the . . . [Full Text of this Article]




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