FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 354:1813-1826 April 27, 2006 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Although hematopoietic stem-cell transplantation was originally conceived more than 50 years ago as a treatment for injury from irradiation and, later, for cancer, associated problems needed to be solved before the procedure could be used clinically. Bone marrow, the source of hematopoietic stem cells, is not a solid organ but is rather diffuse and not directly accessible. Furthermore, hematologic cells can initiate immune reactions that may thwart transplantation.

Hematopoietic stem-cell transplantation is used primarily for hematologic and lymphoid cancers but also for many other disorders (Table 1). In this review, I summarize background information about hematopoietic stem-cell transplantation . . . [Full Text of this Article]

Early Work

Current Knowledge and Theory

Preparative Regimens

Sources of Stem Cells

Cord-Blood Transplantation

Transplantation Involving a Haploidentical Donor

Complications

Early Effects

Delayed Effects

Uses and Results

The Future

Source Information

From the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, the Ohio State University, Columbus.

Address reprint requests to Dr. Copelan at A-437 Starling Loving Hall, 320 W. 10th Ave., Columbus, OH 43210, or at edward.copelan@osumc.edu.

Related Letters:

Hematopoietic Stem-Cell Transplantation
Ellis M. J., Patel U. D., Ende M., Ende F. I., Copelan E. A.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:1070-1071, Sep 7, 2006. Correspondence

This article has been cited by other articles:

• Baerlocher, G. M., Rovo, A., Muller, A., Matthey, S., Stern, M., Halter, J., Heim, D., Rischewski, J., Gratwohl, A., Tichelli, A. (2009). Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex. Blood 114: 219-222 [Abstract] [Full Text]  
• Serikov, V., Hounshell, C., Larkin, S., Green, W., Ikeda, H., Walters, M. C., Kuypers, F. A. (2009). A BRIEF COMMUNICATION: Human Term Placenta as a Source of Hematopoietic Cells. Exp. Biol. Med. 234: 813-823 [Abstract] [Full Text]  
• Wilson, J., Cullup, H., Lourie, R., Sheng, Y., Palkova, A., Radford, K. J., Dickinson, A. M., Rice, A. M., Hart, D. N.J., Munster, D. J. (2009). Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. JEM 206: 387-398 [Abstract] [Full Text]  
• Bratton, S. L. (2009). Risk of Death After Hematopoietic Stem Cell Transplantation. AAP Grand Rounds 21: 6-6 [Full Text]  
• Porta, F., Locatelli, F., Burgio, G. R. (2008). Hematopoietic stem cell transplantation: 40 years of continuous progress and evolution. haematol 93: 1607-1610 [Full Text]  
• Bishop, M. R., Dean, R. M., Steinberg, S. M., Odom, J., Pavletic, S. Z., Chow, C., Pittaluga, S., Sportes, C., Hardy, N. M., Gea-Banacloche, J., Kolstad, A., Gress, R. E., Fowler, D. H. (2008). Clinical evidence of a graft-versus-lymphoma effect against relapsed diffuse large B-cell lymphoma after allogeneic hematopoietic stem-cell transplantation. Ann Oncol 19: 1935-1940 [Abstract] [Full Text]  
• Silva, E. A., Kim, E.-S., Kong, H. J., Mooney, D. J. (2008). Material-based deployment enhances efficacy of endothelial progenitor cells. Proc. Natl. Acad. Sci. USA 105: 14347-14352 [Abstract] [Full Text]  
• Devine, S. M., Vij, R., Rettig, M., Todt, L., McGlauchlen, K., Fisher, N., Devine, H., Link, D. C., Calandra, G., Bridger, G., Westervelt, P., DiPersio, J. F. (2008). Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood 112: 990-998 [Abstract] [Full Text]  
• Armenian, S. H., Bhatia, S. (2008). Cardiovascular disease after hematopoietic cell transplantation - lessons learned. haematol 93: 1132-1136 [Full Text]  
• Tichelli, A., Passweg, J., Wojcik, D., Rovo, A., Harousseau, J.-L., Masszi, T., Zander, A., Bekassy, A., Crawley, C., Arat, M., Sica, S., Lutz, P., Socie, G., on behalf of the EBMT Late Effects Working Party, (2008). Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. haematol 93: 1203-1210 [Abstract] [Full Text]  
• Chung, T, Lim, W-C, Sy, R, Cunningham, I, Trotman, J, Kritharides, L (2008). Subacute cardiac toxicity following autologous haematopoietic stem cell transplantation in patients with normal cardiac function. Heart 94: 911-918 [Abstract] [Full Text]  
• Ballinger, M. N., Hubbard, L. L. N., McMillan, T. R., Toews, G. B., Peters-Golden, M., Paine, R. III, Moore, B. B. (2008). Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation. Am. J. Physiol. Lung Cell. Mol. Physiol. 295: L114-L122 [Abstract] [Full Text]  
• Lazarus, H. M., Phillips, G. L., Herzig, R. H., Hurd, D. D., Wolff, S. N., Herzig, G. P. (2008). High-Dose Melphalan and the Development of Hematopoietic Stem-Cell Transplantation: 25 Years Later. JCO 26: 2240-2243 [Full Text]  
• de Witte, M. A., Jorritsma, A., Swart, E., Straathof, K. C., de Punder, K., Haanen, J. B. A. G., Rooney, C. M., Schumacher, T. N. M. (2008). An Inducible Caspase 9 Safety Switch Can Halt Cell Therapy-Induced Autoimmune Disease. J. Immunol. 180: 6365-6373 [Abstract] [Full Text]  
• Wolfe, J., Hammel, J. F., Edwards, K. E., Duncan, J., Comeau, M., Breyer, J., Aldridge, S. A., Grier, H. E., Berde, C., Dussel, V., Weeks, J. C. (2008). Easing of Suffering in Children With Cancer at the End of Life: Is Care Changing?. JCO 26: 1717-1723 [Abstract] [Full Text]  
• Kenins, L., Gill, J. W., Boyd, R. L., Hollander, G. A., Wodnar-Filipowicz, A. (2008). Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation. JEM 205: 523-531 [Abstract] [Full Text]  
• Liang, S.-L., Lin, M.-T., Hafez, M. J., Gocke, C. D., Murphy, K. M., Sokoll, L. J., Eshleman, J. R. (2008). Application of Traditional Clinical Pathology Quality Control Techniques to Molecular Pathology. J. Mol. Diagn. 10: 142-146 [Abstract] [Full Text]  
• Bridenbaugh, S., Kenins, L., Bouliong-Pillai, E., Kalberer, C. P., Shklovskaya, E., Gratwohl, A., Wodnar-Filipowicz, A. (2008). Clinical stem-cell sources contain CD8+CD3+ T-cell receptor-negative cells that facilitate bone marrow repopulation with hematopoietic stem cells. Blood 111: 1735-1738 [Abstract] [Full Text]  
• Gratwohl, A., Baldomero, H., Schwendener, A., Gratwohl, M., Apperley, J., Niederwieser, D., Frauendorfer, K., for the Joint Accreditation Committee of the Inter, (2007). Predictability of hematopoietic stem cell transplantation rates. haematol 92: 1679-1686 [Abstract] [Full Text]  
• Tichelli, A., Bucher, C., Rovo, A., Stussi, G., Stern, M., Paulussen, M., Halter, J., Meyer-Monard, S., Heim, D., Tsakiris, D. A., Biedermann, B., Passweg, J. R., Gratwohl, A. (2007). Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation. Blood 110: 3463-3471 [Abstract] [Full Text]  
• Paulos, C. M., Kaiser, A., Wrzesinski, C., Hinrichs, C. S., Cassard, L., Boni, A., Muranski, P., Sanchez-Perez, L., Palmer, D. C., Yu, Z., Antony, P. A., Gattinoni, L., Rosenberg, S. A., Restifo, N. P. (2007). Toll-like Receptors in Tumor Immunotherapy. Clin. Cancer Res. 13: 5280-5289 [Abstract] [Full Text]  
• Devetten, M, Armitage, J. (2007). Hematopoietic cell transplantation: progress and obstacles. Ann Oncol 18: 1450-1456 [Abstract] [Full Text]  
• de Wert, G., Liebaers, I., Van de Velde, H. (2007). The Future (R)evolution of Preimplantation Genetic Diagnosis/Human Leukocyte Antigen Testing: Ethical Reflections. Stem Cells 25: 2167-2172 [Abstract] [Full Text]  
• Kochenderfer, J. N., Simpson, J. L., Chien, C. D., Gress, R. E. (2007). Vaccination regimens incorporating CpG-containing oligodeoxynucleotides and IL-2 generate antigen-specific antitumor immunity from T-cell populations undergoing homeostatic peripheral expansion after BMT. Blood 110: 450-460 [Abstract] [Full Text]  
• Weissinger, E. M., Schiffer, E., Hertenstein, B., Ferrara, J. L., Holler, E., Stadler, M., Kolb, H.-J., Zander, A., Zurbig, P., Kellmann, M., Ganser, A. (2007). Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Blood 109: 5511-5519 [Abstract] [Full Text]  
• Gratwohl, A. (2007). At last, an "ointment" for gastrointestinal GVHD?. Blood 109: 4117-4117 [Full Text]  
• Niscola, P., Romani, C., Cupelli, L., Scaramucci, L., Tendas, A., Dentamaro, T., Amadori, S., de Fabritiis, P. (2007). Mucositis in patients with hematologic malignancies: an overview. haematol 92: 222-231 [Abstract] [Full Text]  
• Fung, H. C., Higman, M. A., van Besien, K. (2007). Stem cell transplantation. ASH-SAP 2007: 328-360 [Full Text]  
• Ellis, M. J., Patel, U. D., Ende, M., Ende, F. I., Copelan, E. A. (2006). Hematopoietic stem-cell transplantation.. NEJM 355: 1070-1070 [Full Text]