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Previous Volume 354:1813-1826 April 27, 2006 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although hematopoietic stem-cell transplantation was originally conceived more than 50 years ago as a treatment for injury from irradiation and, later, for cancer, associated problems needed to be solved before the procedure could be used clinically. Bone marrow, the source of hematopoietic stem cells, is not a solid organ but is rather diffuse and not directly accessible. Furthermore, hematologic cells can initiate immune reactions that may thwart transplantation.

Hematopoietic stem-cell transplantation is used primarily for hematologic and lymphoid cancers but also for many other disorders (Table 1). In this review, I summarize background information about hematopoietic stem-cell transplantation . . . [Full Text of this Article]

Early Work

Current Knowledge and Theory

Preparative Regimens

Sources of Stem Cells

Cord-Blood Transplantation

Transplantation Involving a Haploidentical Donor

Complications

Early Effects

Delayed Effects

Uses and Results

The Future

Source Information

From the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, the Ohio State University, Columbus.

Address reprint requests to Dr. Copelan at A-437 Starling Loving Hall, 320 W. 10th Ave., Columbus, OH 43210, or at edward.copelan@osumc.edu.

Related Letters:

Hematopoietic Stem-Cell Transplantation
Ellis M. J., Patel U. D., Ende M., Ende F. I., Copelan E. A.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:1070-1071, Sep 7, 2006. Correspondence

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