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Clinical Implications of Basic Research
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Volume 354:1844-1845 April 27, 2006 Number 17
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Disciplining the Stem Cell into Myogenesis
Terry Partridge, Ph.D.

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Naiveté is a much lauded but equivocal virtue of the stem cell that implies both versatility and — if this quality is to be exploited to clinical advantage — the need for firm discipline. A report by Dezawa and colleagues1 describes the systematic induction of differentiation of adult mesenchymal stem cells from the bone marrow of rats and humans into myoblasts.

The authors used a fairly straightforward protocol of exposing the cells to a cocktail of cytokines known to be promyogenic and then transfecting the cells with the active part of the Notch gene, which is involved in decision making . . . [Full Text of this Article]


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From Généthon, Evry, France.



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