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Previous Volume 354:2074-2075 May 11, 2006 Number 19 Next

Tumor Necrosis Factor in Refractory Asthma

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In our opinion, the randomized clinical trial by Berry et al. (Feb. 16 issue)¹ appears to mitigate the excitement that has been generated in recent years concerning the use of tumor necrosis factor (TNF-) inhibitors in the management of refractory asthma.² In an open-label study,³ 12 weeks of treatment with etanercept resulted in a substantial improvement in symptoms; all but one of the patients were able to discontinue the use of bronchodilators. By contrast, the observed statistically significant improvement in quality-of-life and symptom scores in the trial by Berry et al. is probably not of clinical . . . [Full Text of this Article]

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