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Perspective
Volume 354:109-112 January 12, 2006 Number 2
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Research in the Hot Zone
Robert Steinbrook, M.D.

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Research conducted at biosafety level 4, popularly known as the hot zone, continues to be both revered and feared. Biosafety level 4 laboratories are the places to study dangerous and exotic agents that cannot safely be studied anywhere else, such as pathogens that can be transmitted within a laboratory through the air. This level of biosafety is often required for the development of diagnostic tests, therapies, and vaccines and as the starting point for work on newly recognized agents whose risks have yet to be established.1 At the same time, these laboratories are seen as potential targets of a terrorist . . . [Full Text of this Article]


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Dr. Steinbrook is a national correspondent for the Journal.




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