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Editorial
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Volume 354:191-193 January 12, 2006 Number 2
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Inhaled Cyclosporine — A Breath of Fresh Air?
Malcolm M. DeCamp, Jr., M.D.

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During the past two decades, lung transplantation has evolved from a new investigational intervention performed in fewer than 20 patients per year at one institution to an accepted, albeit complex, therapy for a wide variety of end-stage lung diseases that is performed in more than 1700 patients annually at nearly 150 centers worldwide.1 Early graft failures and deaths of patients were attributable to an amalgam of technical complications, opportunistic infections, and acute rejection. Refinements in surgical technique, enhanced graft preservation, and the routine use of contemporary monitoring and prophylactic and preemptive regimens for opportunistic viruses, fungi, and protozoan organisms have . . . [Full Text of this Article]


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From the Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston.


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