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Previous Volume 354:2151-2164 May 18, 2006 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hearing loss is an etiologically heterogeneous trait with many known genetic and environmental causes.¹ Historically, some environmental causes of hearing loss, such as rubella embryopathy, have been epidemic in nature, establishing that the incidence of congenital deafness can vary widely at various times and among populations. Other important environmental causes of hearing loss include prematurity, prenatal and postnatal infections, head trauma, subarachnoid hemorrhage, and pharmacologic ototoxicity. Genetic causes account for at least 50 to 60 percent of childhood hearing loss in developed countries and can be classified according to the pattern of inheritance, the presence (syndromic) or absence (nonsyndromic) of . . . [Full Text of this Article]

Prevalence of Hearing Loss in Newborns

Limitations of Existing Screening Programs

Genetic Causes of Syndromic Hearing Loss

Genetic Causes of Nonsyndromic Hearing Loss

Cause of the High Prevalence of Deafness from Mutations in GJB2

Environmental Causes of Prelingual Hearing Loss

Improving Detection of Late-Onset Prelingual Hearing Loss

Source Information

From the Departments of Obstetrics, Gynecology, and Reproductive Biology and Pathology, Brigham and Women's Hospital and Harvard Medical School — both in Boston (C.C.M.); and the Department of Human Genetics, Pediatrics, Medicine, and Otolaryngology, Medical College of Virginia, Virginia Commonwealth University, Richmond (W.E.N.).

Address reprint requests to Dr. Nance at the Department of Human Genetics, Sanger Hall, 11th floor, 1101 E. Marshall St., P.O. Box 980033, Richmond, VA 23298-0033, or at nance@mail2.vcu.edu.

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