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Volume 354:2186 May 18, 2006 Number 20
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Trastuzumab Treatment in Breast Cancer

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 by Joensuu, H.
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To the Editor: Joensuu and colleagues (Feb. 23 issue)1 report the provocative finding that a short treatment with trastuzumab (for nine weeks) combined with chemotherapy is effective in the adjuvant treatment of HER2-positive breast cancer. At a median follow-up of three years, the effect on event-free survival was in the range of that reported with the administration of trastuzumab for a year after adjuvant chemotherapy.2,3 However, this study lacks a randomized comparison with established regimens; neither the regimen of vinorelbine followed by three cycles of fluorouracil, epirubicin, and cyclophosphamide (FEC) nor the docetaxel–FEC sequence can be considered "conventional" adjuvant . . . [Full Text of this Article]




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