Sixteen years ago, the results of the Prospective Investigationof Pulmonary Embolism Diagnosis (PIOPED) study1 were published.That large-scale, multicenter trial definitively establishedthe diagnostic characteristics of ventilationperfusionscintigraphy of the lung, as compared with pulmonary angiography,for the diagnosis of pulmonary embolism. It was also the firsttrial to provide direct evidence that clinical assessment hasa role beyond merely evoking pulmonary embolism as a diagnosticpossibility and allows for the stratification of patients intothree pretest categories of probability corresponding to anincreasing prevalence of pulmonary embolism.
From the Divisions of General Internal Medicine (A.P.) and Angiology and Hemostasis (H.B.), Department of Internal Medicine, Geneva University Hospital and Geneva Faculty of Medicine, Geneva.
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