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Volume 354:2387-2389 June 1, 2006 Number 22
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Natalizumab for Relapsing Multiple Sclerosis

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To the Editor: As Ropper pointed out in his editorial (March 2 issue),1 the three articles on the use of natalizumab in that issue of the Journal are pivotal, but his conclusion that natalizumab is "a potent treatment for multiple sclerosis" may be too sanguine. The similar entry criteria, treatment, and methods of analysis permit clinically useful conclusions to be drawn from the placebo-controlled study of natalizumab by Polman et al.2 and the study of natalizumab plus interferon beta by Rudick et al.3 A comparison of Figure 2 in both studies is illustrative. In the study by Polman et al., . . . [Full Text of this Article]




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