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Volume 354:2390-2391 June 1, 2006 Number 22
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Denosumab in Postmenopausal Women with Low Bone Mineral Density

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by McClung, M. R.
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To the Editor: McClung et al. (Feb. 23 issue)1 do not adequately report adverse events in their article on denosumab in postmenopausal women with low bone mineral density. They state that no significant differences in adverse events were observed among the groups. However, there were six cases of neoplasm in the denosumab group (mentioned only in Table 2 but not in the Discussion section) and none in the other groups. There were numerically more serious adverse events in the denosumab group, as well as more withdrawals because of these events.

The authors do not discuss the possibility of a type . . . [Full Text of this Article]



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