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Previous Volume 354:2463-2472 June 8, 2006 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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DNA microarray analysis was first described in the mid-1990s as a means to probe the expression of thousands of genes simultaneously^1,2 and was quickly adopted by the research community for the study of a wide range of biologic processes. Most of the early studies had a simple and powerful design: to compare two biologic classes in order to identify the differential expression of the genes in them — genes with potential relevance to a wide range of biologic processes, such as the progression of cancer,^3,4,5,6 the causes of asthma,^7,8,9 heart disease,^10,11,12 and neuropsychiatric disorders,^{13,14,15,16,17} and the analysis of factors associated . . . [Full Text of this Article]

Collection, Transformation, and Representation of the Data

Identifying Patterns of Expression

Class Discovery

Classification

Validation

Limitations and Success of Classification

A Proliferation of "-omics"

Source Information

From the Dana–Farber Cancer Institute and Harvard School of Public Health — both in Boston.

Address reprint requests to Dr. Quackenbush at the Dana–Farber Cancer Institute, 44 Binney St., Boston, MA 02115, or at johnq@jimmy.harvard.edu.

Related Letters:

Microarray Analysis and Tumor Classification
Lin D. W., Nelson P. S., Quackenbush J.
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N Engl J Med 2006; 355:960, Aug 31, 2006. Correspondence

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