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Previous Volume 354:2498-2500 June 8, 2006 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Angiotensin-converting–enzyme (ACE) inhibitors are among the most widely prescribed antihypertensive agents in the United States, but when used in the second half of pregnancy, they can cause oligohydramnios, fetal growth retardation, pulmonary hypoplasia, joint contractures, hypocalvaria and neonatal renal failure, hypotension, and death.^1,2,3 These effects result from blockade of the conversion of angiotensin I to angiotensin II in the developing fetal kidneys.³ A strikingly similar pattern of fetal anomalies has been reported after treatment of women in the second or third trimester of pregnancy with angiotensin II–receptor antagonists,^1,4 drugs that block the fetal renin–angiotensin system at a different point.

In . . . [Full Text of this Article]

Source Information

From the Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

This article has been cited by other articles:

• Murphy, H. R, Temple, R. C, Roland, J. M (2007). Improving outcomes of pregnancy for women with type 1 and type 2 diabetes. British Journal of Diabetes & Vascular Disease 7: 38-42 [Abstract]  
• (2006). ACE Inhibitors and Birth Defects: Unsafe in Any Trimester. JWatch Women's Health 2006: 1-1 [Full Text]  
• (2006). ACE Inhibitors Are Teratogenic in the First Trimester. Journal Watch Cardiology 2006: 1-1 [Full Text]  
• (2006). Safety of First-Trimester Exposure to ACE Inhibitors. JWatch General 2006: 3-3 [Full Text]