The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Correspondence
PreviousPrevious
Volume 354:2611-2613 June 15, 2006 Number 24
NextNext

Depression — Augmentation or Switch after Initial SSRI Treatment

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-Related Article
by Rubinow, D. R.
-Related Article
by Rush, A. J.
-Related Article
by Trivedi, M. H.
-PubMed Citation
To the Editor: The report on the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial by Rush et al. (March 23 issue)1 advances the evidence base for the treatment of major depression. However, I believe it would be overreaching and incorrect to characterize the results of the study of drug treatment after initial treatment with selective serotonin-reuptake inhibitors (SSRIs) as definitive, owing to the statistical underpowering of the design. This study seems to have the same shortcomings as do other large studies, in that the authors incorrectly estimated the differences in remission among the various therapies that they tested. Rush . . . [Full Text of this Article]



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.