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Volume 354:2613-2616 June 15, 2006 Number 24
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Invariant Natural Killer T Cells in Bronchial Asthma

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 by Akbari, O.
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To the Editor: We have not found a remarkably high proportion of CD1d-restricted natural killer T cells (>60 percent of CD3+ cells) in bronchoalveolar-lavage specimens from patients with allergic asthma, as reported by Akbari et al. (March 16 issue).1 In five patients with allergic asthma, we found that only 0.4 to 2.1 percent of lymphocytes in bronchoalveolar-lavage fluid were natural killer T cells, on the basis of costaining with 6B11 and V{alpha}24 antibodies (see Figure 1 of the Supplementary Appendix, available with the full text of this letter at www.nejm.org). We believe this discrepancy may result from fact . . . [Full Text of this Article]


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