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Previous Volume 354:2707-2709 June 22, 2006 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Clinically significant interstitial lung disease affects patients with systemic sclerosis (scleroderma) and is a cause of morbidity and mortality in approximately 40 percent of these patients.¹ Management of this condition remains difficult and controversial.^2,3 In this issue of the Journal, Tashkin and colleagues⁴ report the results of a multicenter, placebo-controlled trial of oral cyclophosphamide in patients with well-defined, symptomatic scleroderma-related interstitial lung disease and alveolitis. They document small but statistically significant improvements in lung function and symptoms with cyclophosphamide administered over the course of one year — the first positive results of a placebo-controlled trial in this field.

How should . . . [Full Text of this Article]

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From the Division of Pulmonary and Critical Care Medicine (F.J.M.) and the Division of Rheumatology, Department of Internal Medicine (W.J.M.), University of Michigan Health System, Ann Arbor.

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