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Previous Volume 354:2721-2723 June 22, 2006 Number 25 Next

Transforming Growth Factor Signaling, Vascular Remodeling, and Hypertension

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Hypertension affects more than 1 billion adults worldwide and is the leading cause of preventable death. Despite the plethora of drugs available, the disease is adequately controlled in only about one third of patients. Hormones and vasoactive peptides, like lead actors in a drama, have garnered much attention in the context of the pathogenesis of hypertension. A recent study by Zacchigna et al.¹ has now brought to center stage a multifunctional cytokine, transforming growth factor (TGF-).

TGF- is a ubiquitously expressed member of a superfamily of proteins critical to developmental processes. It regulates cell growth and differentiation, inflammation, and . . . [Full Text of this Article]

Source Information

From Weill Medical College of Cornell University, New York (P.A., M.S.), and the Theresa and Eugene Lang Center for Research and Education, New York Hospital Queens, Flushing (P.A.).

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