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Correspondence
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Volume 354:2729-2731 June 22, 2006 Number 25
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Clinical and Genetic Characteristics of Patients with Neurofibromatosis Type 1 and Pheochromocytoma

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To the Editor: Pheochromocytoma occurs in approximately 1 percent of patients with neurofibromatosis type 1.1 Accordingly, germ-line mutations in the NF1 gene — the susceptibility gene for neurofibromatosis type 1 — are assumed to be one of the heritable causes of pheochromocytoma.2

Given the previous lack of relevant molecular data, we established and analyzed a registry for patients with neurofibromatosis type 1 and pheochromocytoma in collaboration with colleagues from 20 centers in Germany, other European countries, and the United States. We compared the findings for patients with neurofibromatosis type 1 with those for patients with other pheochromocytoma-related syndromes, including von . . . [Full Text of this Article]


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