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Previous Volume 354:296-297 January 19, 2006 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The antibiotics currently used in clinical practice are either bacteriostatic (that is, they inhibit bacterial growth) or bacteriocidal (that is, they kill bacteria). These antibiotics work by inhibiting bacterial processes such as protein synthesis or DNA replication that are essential for cell growth. Over the past two decades, however, fundamental advances in understanding the mechanisms and regulation of bacterial virulence have led to an alternative approach to antimicrobial therapy: inhibition of bacterial virulence without inhibition of bacterial growth. Using Vibrio cholerae, the agent of the diarrheal disease cholera, as a test organism, Hung et. al.¹ have shown that a small . . . [Full Text of this Article]

Source Information

From the Departments of Microbiology and Medicine, Tufts University School of Medicine, Boston.

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