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Previous Volume 354:304-305 January 19, 2006 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Pass et al. (Oct. 13 issue)¹ report that elevated osteopontin levels in workers with pleural disease who have been exposed to asbestos support a diagnosis of mesothelioma. The authors acknowledge that other cancers express osteopontin, and they mention the need for further studies. The expression of osteopontin in numerous benign inflammatory and fibrotic lung diseases,² which considerably limits the potential use of osteopontin as a tumor marker, was not discussed. In addition to the osteopontin levels associated with lung carcinoma, similar levels are seen in tuberculosis, interstitial lung diseases, and cardiac disease.^2,3 These clinical entities pose diagnostic . . . [Full Text of this Article]

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