LRRK2 G2019S as a Cause of Parkinson's Disease in Ashkenazi Jews

doi:10.1056/NEJMc055509

Volume 354:424-425		January 26, 2006		Number 4

LRRK2 G2019S as a Cause of Parkinson's Disease in Ashkenazi Jews

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To the Editor: Most cases of Parkinson's disease are consideredsporadic and idiopathic, although there is evidence of familialaggregation, and several monogenic forms have been identified.¹Recently, several pathogenic mutations in the highly conservedleucine-rich repeat kinase 2 gene (LRRK2) have been associatedwith autosomal dominant, late-onset Parkinson's disease.¹ Ofthese, the G2019S substitution is the most frequently reported.²It occurs in about 1 percent of unselected cases and 3 to 6percent of familial cases of Parkinson's disease in personsprimarily of European ancestry² but in 7 of 17 cases of familialdisease in persons from . . . [Full Text of this Article]

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