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Previous Volume 354:524-525 February 2, 2006 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Calin et al. (Oct. 27 issue)¹ report on genomic mutations within microRNA loci in patients with chronic lymphocytic leukemia (CLL). We believe that the frequency with which such mutations can be found was not accurately estimated and that some of the cell-based data were unsound. Among 69 samples of CLL cells, in which one copy of chromosome 13q was lost, we did not identify mutations within a 581-bp segment encompassing the miR-15a–16-1 gene. We also consider it very surprising that a single substitution outside the pri-miR-16-1 hairpin abolished the expression of both miR-15a and miR-16-1 as presented . . . [Full Text of this Article]

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