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Previous Volume 354:610-621 February 9, 2006 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Chemokines (chemotactic cytokines) are small heparin-binding proteins that direct the movement of circulating leukocytes to sites of inflammation or injury. During the eight years since chemokines and chemokine receptors were last reviewed in the Journal,¹ a vast expansion in the understanding of chemokine biology has occurred. Originally studied because of their role in inflammation, chemokines and their receptors are now known to play a crucial part in directing the movement of mononuclear cells throughout the body, engendering the adaptive immune response and contributing to the pathogenesis of a variety of diseases. Chemokine receptors are some of the most tractable drug . . . [Full Text of this Article]

Chemokines, Chemokine Receptors, and Innate Immunity

The ELR+ CXC Chemokines

Monocyte Chemoattractant Proteins

CCR7

Movement of Lymphocytes to Skin and Gut

Coreceptors for HIV-1

Inflammatory Diseases

Multiple Sclerosis

Metabolic Disorders

Atherosclerosis

Insulin Resistance and Obesity-Induced Diabetes

Therapeutic Strategies

Source Information

From the Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco — both in San Francisco (I.F.C.); and the Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, the Mellen Center for MS Treatment and Research, and the Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland (R.M.R.).

Address reprint requests to Dr. Charo at the Gladstone Institute of Cardiovascular Disease, 1650 Owens St., San Francisco, CA 94158, or at icharo@gladstone.ucsf.edu; or to Dr. Ransohoff at the Department of Neurosciences, NC30, the Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, or at ransohr@ccf.org.

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