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Correspondence
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Volume 354:646-648 February 9, 2006 Number 6
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Medical Management of Depression

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by Mann, J. J.
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To the Editor: In his otherwise comprehensive and well-referenced review of the medical management of depression, Mann (Oct. 27 issue)1 notes both in the text and in the treatment algorithm (Figure 2 in the article) the use of thyroid hormone supplements "even in the absence of clinical hypothyroidism for the purpose of enhancing antidepressant action." This statement has not a single reference to substantiate it.

When a person who is euthyroid takes thyroid supplements, all he or she does is replace the endogenous production of thyroid hormone, with no resultant change in the patient's thyroid status or function. Thus, I . . . [Full Text of this Article]



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