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Previous Volume 354:758-760 February 16, 2006 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Adjuvant treatment for patients after resection of high-risk and regionally metastatic melanoma remains suboptimal. Despite the Food and Drug Administration's approval of high-dose interferon alfa-2b, the substantial toxicity of the therapy and the fact that its benefit is limited to 20 to 30 percent of patients at risk have hindered its general acceptance.

Attempts to identify patients who benefit from adjuvant treatment with interferon alfa-2b have been disappointing to date. Although analyses of individual studies suggest that the benefit of high-dose interferon alfa-2b might be restricted to certain subgroups of patients, on the basis of the number of melanoma-involved lymph . . . [Full Text of this Article]

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From Beth Israel Deaconess Medical Center, Boston.

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