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Previous Volume 354:761-763 February 16, 2006 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Chronic inflammation of the intestine and colorectal cancer are closely associated. The risk of colorectal cancer among patients with ulcerative colitis is an order of magnitude higher than the risk among those without it. Indeed, ulcerative colitis ranks among the top three high-risk conditions for colorectal cancer, together with the syndromes of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. Although the relationship of the other two conditions to colorectal cancer has a well-understood genetic basis, the association of ulcerative colitis with colorectal cancer is not believed to result from such an underlying predisposition. Rather, the process of chronic inflammation . . . [Full Text of this Article]

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From the Netherlands Institute for Developmental Biology, Utrecht, the Netherlands.

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